背景资料: Aminoacylase-1 is a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and acyl group, and has b氨基酰化酶1重组蛋白是在大肠杆菌中重组表达的,是一条单链、非糖基化的多肽链,包含有428个氨基酸(1-408 a.a.),分子量为21.7kDa.该氨基酰化酶1重组蛋白的N末端融合了一个20个氨基酸的His标签,该蛋白最终由标准的色谱技术纯化出.n postulated to function in the catabolism and salvage of acylated amino acids. ACY1 has b氨基酰化酶1重组蛋白是在大肠杆菌中重组表达的,是一条单链、非糖基化的多肽链,包含有428个氨基酸(1-408 a.a.),分子量为21.7kDa.该氨基酰化酶1重组蛋白的N末端融合了一个20个氨基酸的His标签,该蛋白最终由标准的色谱技术纯化出.n assigned to chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer(SCLC), and its expression has b氨基酰化酶1重组蛋白是在大肠杆菌中重组表达的,是一条单链、非糖基化的多肽链,包含有428个氨基酸(1-408 a.a.),分子量为21.7kDa.该氨基酰化酶1重组蛋白的N末端融合了一个20个氨基酸的His标签,该蛋白最终由标准的色谱技术纯化出.n reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and ACY1 is the first member of a new family of zinc-binding enzymes.