背景资料: 4-1BBL is a transmembrane cytokine that is part of the tumor necrosis factor (TNF) ligand family. 4-1BBL is a bidirectional signal transducer that performs as a ligand for TNFRSF9,which is a costimulatory receptor molecule in T lymphocytes. TNFSF9 and its TNFRSF9 take part in the antigen presentation development and in the generation of cytotoxic T cells. 4-1BBR is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. TNFSF9 reactivates anergic T lymphocytes as well as promoting T lymphocyte proliferation. 4-1BB Ligand is n人4-1BB配体重组蛋白的N末端融合了一个37个氨基酸的His标签,该蛋白是在大肠杆菌中重组表达的,是一条单链、非糖基化的多肽链,包含有222个氨基酸片段(71-254 a.a.),分子量为23.8kDa.该人4-1BB配体重组蛋白最终由标准的色谱技术纯化出.ded for the optimal CD8 responses in CD8 T cells. 4-1BBL is expressed in carcinoma cell lines,and is thought to be involved in T cell-tumor cell interaction. 4-1BBL is expressed by activated B cells,macrophages,dendritic cells,activated T cells,neurons and astrocytes. The interaction of 4-1BB with TNFRSF9 strongly regulates immunity and has b人4-1BB配体重组蛋白的N末端融合了一个37个氨基酸的His标签,该蛋白是在大肠杆菌中重组表达的,是一条单链、非糖基化的多肽链,包含有222个氨基酸片段(71-254 a.a.),分子量为23.8kDa.该人4-1BB配体重组蛋白最终由标准的色谱技术纯化出.n proposed to preferentially control T cell responses based on studies in various murin