Mechanisms of MCL-1 protein stability induced by MCL-1 antagonists in B-cell malignancies: S.I. Tantawy, et al.; Clin. Cancer Res.
29, 446 (2023),
Abstract;
SUMOylation-mediated PSME3-20S proteasomal degradation of transcription factor CP2c is crucial for cell cycle progression: S.H. Son, et al.; Sci. Adv.
9, eadd4969 (2023),
Abstract;
U-box E3 ubiquitin ligase PUB8 attenuates abscisic acid responses during early seedling growth: Z. Li, et al.; Plant Physiol.
191, 2519 (2023),
Abstract;
DEC1 represses cardiomyocyte hypertrophy by recruiting PRP19 as an E3 ligase to promote ubiquitination-proteasome-mediated degradation of GATA4: L. Cheng, et al.; J. Mol. Cell. Cardiol.
169, 96 (2022),
Abstract;
FBXW7-mediated ERK3 degradation regulates the proliferation of lung cancer cells: H.J. Ann, et al.; Exp. Mol. Med.
54, 35 (2022),
Abstract;
Rice OsUBR7 modulates plant height by regu lating histone H2B monoubiquitination and cell proliferation: Y. Zheng, et al.; Plant. Commun.
3, 100412 (2022),
Abstract;
RNF115 Inhibits the Post-ER Trafficking of TLRs and TLRs-Mediated Immune Responses by Catalyzing K11-Linked Ubiquitination of RAB1A and RAB13: Z.D. Zhang, et al.; Adv. Sci. (Weinh.)
9, e2105391 (2022),
Abstract;
SBDS interacts with RNF2 and is degraded through RNF2-dependent ubiquitination: Y. Sera, et al.; Biochem. Biophys. Res. Commun.
598, 119 (2022),
Abstract;
TRAF4 hyperactivates HER2 signaling and contributes to Trastuzumab resistance in HER2-positive breast cancer: Y. Gu, et al.; Oncogene
41, 4119 (2022),
Abstract;
Ursodeoxycholic acid reduces antitumor immunosuppression by inducing CHIP-mediated TGF-β degradation: Y. Shen, et al.; Nat. Commun.
13, 3419 (2022),
Abstract;
USP20 mitigates ischemic stroke in mice by suppressing neuroinflammation and neuron death via regulating PTEN signal: R. Pan, et al.; Int. Immunopharmacol.
103, 107840 (2022),
Abstract;
RPA2 winged-helix domain facilitates UNG-mediated removal of uracil from ssDNA; implications for repair of mutagenic uracil at the replication fork: B. Kavli, et al.; Nucleic Acids Res.
49, 3948 (2021),
Abstract;
The RING-type protein BOI negatively regulates the protein level of a CC-NBS-LRR in Arabidopsis: J. Huang, et al.; Biochem. Biophys. Res. Commun.
578, 104 (2021),
Abstract;
The RNA-binding protein HuR is a novel target of Pirh2 E3 ubiquitin ligase: A. Daks, et al.; Cell Death Dis.
12, 581 (2021),
Abstract;
Full Text
Crystal structure of GCN5 PCAF N-terminal domain reveals atypical ubiquitin ligase structure: S. Toma-Fukai, et al.; J. Biol. Chem.
295, 14360 (2020),
Abstract;
Ehrlichia chaffeensis TRP120-mediated ubiquitination and proteasomal degradation of tumor suppressor FBW7 increases oncoprotein stability and promotes infection: J.Y. Wang, et al.; PLoS Pathog.
16, e1008541 (2020),
Abstract;
Full Text
Enhanced sustainable green revolution yield via nitrogen-responsive chromatin modulation in rice: K. Wu, et al.; Science
367, eaaz2046 (2020),
Abstract;
RNF41 regulates the damage recognition receptor Clec9A and antigen cross-presentation in mouse dendritic cells: K.M. Tullett, et al.; Elife
9, e63452 (2020),
Abstract;
Full Text
TRIB3 supports breast cancer stemness by suppressing FOXO1 degradation and enhancing SOX2 transcription: J.M. Yu, et al.; Nat. Commun.
10, 5720 (2019),
Abstract;
Full Text
A Lotus japonicus E3 ligase interacts with the Nod Factor Receptor 5 and positively regulates nodulation: D. Tsikou, et al.; BMC Plant Biol.
18, 217 (2018),
Abstract;
Full Text
Autoubiquitination of feline E3 ubiquitin ligase BCA2: W. Wang, et al.; Gene
638, 1 (2018),
Abstract;
The deubiquitinating enzyme cylindromatosis mitigates nonalcoholic steatohepatitis: Y.X. Ji, et al.; Nat. Med.
24, 213 (2018),
Abstract;
The E3 Ligase RING1 Targets p53 for Degradation and Promotes Cancer Cell Proliferation and Survival: J. Shen, et al.; Cancer Res.
78, 359 (2018),
Abstract;
Vpr Targets TET2 for Degradation by CRL4VprBP E3 Ligase to Sustain IL-6 Expression and Enhance HIV-1 Replication: L. Lv, et al.; Mol. Cell
70, 961 (2018),
Abstract;
BTK blocks the inhibitory effects of MDM2 on p53 activity: M. Rada, et al.; Oncotarget
8, 106639 (2017),
Abstract;
Full Text
E3 Ubiquitin ligase ZNRF4 negatively regulates NOD2 signalling and induces tolerance to MDP: P. Bist, et al.; Nat. Commun.
8, 15865 (2017),
Abstract;
Full Text
MKRN2 is a novel ubiquitin E3 ligase for the p65 subunit of NF-κB and negatively regulates inflammatory responses: C. Shin, et al.; Sci. Rep.
7, 46097 (2017),
Abstract;
Full Text
Skp2-Mediated Stabilization of MTH1 Promotes Survival of Melanoma Cells upon Oxidative Stress: J.Y. Wang, et al.; Cancer Res.
77, 6225 (2017),
Abstract;
The Ubiquitin E3 Ligase TRAF6 Exacerbates Ischemic Stroke by Ubiquitinating and Activating Rac1: T. Li, et al.; J. Neurosci.
37, 12123 (2017),
Abstract;
Hepatocyte TRAF3 promotes liver steatosis and systemic insulin resistance through targeting TAK1-dependent signalling: P.X. Wang, et al.; Nat. Commun.
7, 10592 (2016),
Application(s): In vitro ubiquitination assays,
Abstract;
Full Text
K63-polyubiquitinated HAUSP deubiquitinates HIF-1α and dictates H3K56 acetylation promoting hypoxia-induced tumour progression: H.T. Wu, et al.; Nat. Commun.
7, 13644 (2016),
Abstract;
Full Text
Loss of NEDD4 contributes to RTP801 elevation and neuron toxicity: implications for Parkinson's disease: M. Canal, et al.; Oncotarget
7, 58813 (2016),
Abstract;
Full Text
The ubiquitin E3 ligase TRAF6 exacerbates pathological cardiac hypertrophy via TAK1-dependent signalling: Y.X. Ji, et al.; Nat. Commun.
7, 11267 (2016),
Abstract;
Full Text
Host cell-catalyzed S-palmitoylation mediates Golgi targeting of the Legionella ubiquitin ligase GobX: Y.H. Lin, et al.; J. Biol. Chem.
290, 25766 (2015),
Application(s): Western Blot,
Abstract;
Full Text
Negative Regulation of CARD11 Signaling and Lymphoma Cell Survival by the E3 Ubiquitin Ligase RNF181: S.M. Pedersen, et al.; Mol. Cell. Biol.
36, 794 (2015),
Abstract;
Full Text
TRIM30α Is a Negative-Feedback Regulator of the Intracellular DNA and DNA Virus-Triggered Response by Targeting STING: Y. Wang, et al.; PLoS Pathog.
11, e1005012 (2015),
Application(s): In vitro ubiquitination assay,
Abstract;
Full Text
TRIM35 negatively regulates TLR7- and TLR9-mediated type I interferon production by targeting IRF7: Y. Wang, et al.; FEBS Lett.
589, 1322 (2015),
Application(s): In vitro ubiquitination assay,
Abstract;
Parkin loss of function contributes to RTP801 elevation and neurodegeneration in Parkinson's disease: J. Romaní-Aumedes, et al.; Cell Death Dis.
5, e1364 (2014),
Abstract;
Rlim, an E3 ubiquitin ligase, influences the stability of Stathmin protein in human osteosarcoma cells: X. Chen, et al.; Cell Signal.
26, 1532 (2014),
Abstract;
Stability of the human pregnane X receptor is regulated by E3 ligase UBR5 and serine/threonine kinase DYRK2: S.S. Ong, et al.; Biochem. J.
459, 193 (2014),
Abstract;
Ubiquitin-proteasome-mediated degradation of S-RNase in a solanaceous cross-compatibility reaction: T. Entani, et al.; Plant J.
78, 1014 (2014),
Abstract;
E3 ubiquitin ligase RNF126 promotes cancer cell proliferation by targeting the tumor suppressor p21 for ubiquitin-mediated degradation: X. Zhi, et al.; Cancer Res.
73, 385 (2013),
Abstract;
The E3 ubiquitin ligase MARCH8 negatively regulates IL-1β-induced NF-κB activation by targeting the IL1RAP coreceptor for ubiquitination and degradation: R. Chen, et al.; Proc. Natl. Acad. Sci. U.S.A.
109, 14128 (2012),
Abstract;
Full Text
TRIM32 protein modulates type I interferon induction and cellular antiviral response by targeting MITA/STING protein for K63-linked ubiquitination: J. Zhang, et al.; J. Biol. Chem.
287, 28646 (2012),
Abstract;
Cullin 4B protein ubiquitin ligase targets peroxiredoxin III for degradation: X. Li, et al.; J. Biol. Chem.
286, 32344 (2011),
Abstract;
Full Text
Tripartite motif 8 (TRIM8) modulates TNFα- and IL-1β-triggered NF-κB activation by targeting TAK1 for K63-linked polyubiquitination: Q. Li, et al.; Proc. Natl. Acad. Sci. U.S.A.
108, 19341 (2011),
Abstract;
Full Text
1-Benzyl-1,2,3,4-tetrahydroisoquinoline binds with tubulin beta, a substrate of parkin, and reduces its polyubiquitination: R. Kohta, et al.; J. Neurochem.
114, 1291 (2010),
Abstract;
Pasteurella multocida Toxin-induced Pim-1 expression disrupts suppressor of cytokine signalling (SOCS)-1 activity: D. Hildebrand, et al.; Cell. Microbiol.
12, 1732 (2010),
Abstract;
The E3 ubiquitin ligase RNF5 targets virus-induced signaling adaptor for ubiquitination and degradation: B. Zhong, et al.; J. Immunol.
184, 6249 (2010),
Abstract;
Full Text
The Fbw7 tumor suppressor targets KLF5 for ubiquitin-mediated degradation and suppresses breast cell proliferation: D. Zhao, et al.; Cancer Res.
70, 4728 (2010),
Abstract;
Full Text
REUL is a novel E3 ubiquitin ligase and stimulator of retinoic-acid-inducible gene-I: D. Gao, et al.; PLoS One
4, e5760 (2009),
Abstract;
Full Text