LDL

产品英文名称：
Low Density Lipoprotein

英文简称:
LDL

中文名称:
人低密度脂蛋白

背景资料:
lipoprotein that transports cholesterol and triglycerides from the liver to peripheral tissues. LDL （like all lipoproteins） facilitates the movement of fats and cholesterol within the water based solution of the blood stream. Each natural LDL particle contains a single Apo B-100 molecule （apolipoprotein B-100 is a protein with 4536 amino acid residues） that circulates the fatty acids and kHuman Low Density Lipoprotein （LDL） produced in Human plasma.ps them soluble in the aqueous environment. Additionally， the LDL core is highly-hydrophobic， consisting of linoleate （a polyunsaturated fatty acid） and about 1500 esterified cholesterol molecules. This core is enclosed by a shell of phospholipids and unesterified cholesterol in addition to a single copy of B-100 large protein （514 kD）. Even though the LDL particles are approximately 22 nm in diameter and have a mass of about 3 million Daltons， they have a mass and size distribution since the LDL particles contain a varying number of fatty acids. LDL receptors are synthesized and placed in the plasma membrane when a cell requires cholesterol. The LDL receptors scatter frHuman Low Density Lipoprotein （LDL） produced in Human plasma.ly until they link to clathrin-coated pits. LDL particles in the blood stream attach to these extracellular LDL receptors. The clathrin-coated pits at that time form vesicles that are endocytosed into the cell. Once the clathrin coat is dropped， the vesicles transport the LDL and their receptors to early endosomes， onto late endosomes to lysosomes. At this point the cholesterol esters in the LDL are hydrolysed. The LDL receptors are recovered back to the plasma membrane. Since LDLs convey cholesterol to the arteries and can be retained there by arterial proteoglycans initializing the formation of plaques， increased levels are linked to atherosclerosis， and thus heart attack， stroke， and peripheral vascular disease. And so， cholesterol within LDL lipoproteins is habitually called "bad" cholesterol. This is a misconception since the cholesterol transported on LDL is the same as the one transported on other lipoprotein particles， it is in itself not "bad"， rather it is how and where the cholesterol is being transported， and in what amounts ultimately， which causes adverse e人血浆中提取纯化ects. HDL / LDL ratio can give an indication of risk for arteriosclerosis.

产品描述:
Human Low Density Lipoprotein （LDL） produced in Human plasma.
来源宿主:
人血浆中提取纯化

序列:


溶解建议:
Yellow to orange liquid.

保存建议：
Human LDL although stable at 4℃ for 1 week， should be stored desiccated below -15℃. （short term i.e. < 3 months） and below -70℃ for long term.
其他简介：

  ProSpec是一家全球著名细胞因子蛋白及相关抗体生产和研发品牌。ProSpec的生产和研发工厂位于以色列，专注于蛋白（重组及合成）生产研发，其独有的细菌和哺乳动物表达和蛋白折叠技术使其能在17年内成长为国际一流的科研级蛋白供应商。目前ProSpec可以提供细胞因子，生长因子，激素，信号蛋白，病毒抗原等近800种重组蛋白和100多种抗体，是世界上提供蛋白品种最多的公司之一，领先的生产工艺和规模使其可以提供毫克到克级蛋白，价格优于同类公司。绝大部分产品是天然成熟型蛋白，而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液，ProSpec-Tany绝大部分产品没有添加保护剂或盐，这就对工艺提出了更高的要求。同时，ProSpec-Tany绝大部分产品为冻干粉，因此易于运输和保存。
上海淳麦生物为ProSpec国内代理销售经销商，详细的产品信息请和我们联系：免费热线：4006815880 微信电话 13770640776