产品英文名称: Recombinant Human Glycine N-Methyltransferase
英文简称: GNMT
中文名称: 重组人甘氨酸-N-甲基转移酶
背景资料: GNMT is an enzyme that catalyzes the conversion of S-adenosyl-L-methionine with glycine to S-adenosyl-L-homocysteine and sarcosine. GNMT is located in the cytoplasm and acts as a homotetramer. Defects in the GNMT gene causes of GNMT deficiency(hypermethioninemia). GNMT a大肠杆菌中重组表达ects DNA methylation by regulating the ratio of S-adenosylmethionine to S-adenosylhomocystine and is involved in the detoxification pathway in liver cells. GNMT expression is diminished in human hepatocellular carcinoma(HCC). GNMT catalyzes the methylation of glycine by using s- adenosylmethionine(adomet) to form n-methylglycine(sarcosine) with the concomitant production of s-adenosylhomocysteine(adohcy). GNMT plays an essential role in the regulation of tissue concentration of adomet and of metabolism of methionine.