产品英文名称: Recombinant Human Formiminotransferase Cyclodeaminase
英文简称: FTCD
中文名称: 重组人亚胺甲基转移酶环脱氨酶
背景资料: Formiminotransferase cyclodeaminase is an enzyme which catalyzes the conversion of formiminoglutamateand tetrahydrofolateinto formiminotetrahydrofolateand glutamate.Formiminotransferase cyclodeaminase, a bifunctional enzyme of tetrahydrofolate synthesis, is the target antigen of anti-LC1(liver cytosol antigen type 1) autoantibodies. Presence of LC1 autoantibodies is a marker for type 2 autoimmune hepatitis(for which anti-LKM 1/cytochrome P450 2D6 autoantibodies are a further marker).Serum LC1 autoantibody concentrations appear to fluctuate in parallel with aminotransferase levels, a particularly intriguing observation that suests a possible role of LC1 autoreactivity in the pathogenic mechanism leading to hepatocyte injury.