背景资料: IL10 is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic e大肠杆菌中重组表达ects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines,MHC class II Ags,and costimulatory molecules on macrophages. It also enhances B cell survival,proliferation,and antibody production. This cytokine can block NF-kappa B activity,and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suThe sequence of the first five N-terminal amino acids was determined and was found to be Met-Ser-Ile-Lys-Ser.ested the function of this cytokine as an essential immunoregulator in the intestinal tract.