HIV-1 gp120

产品英文名称：
Recombinant HIV-1 gp120 nef Mosaic

英文简称:
HIV-1 gp120

中文名称:
重组HIV-1 gp120 nef嵌合体蛋白

背景资料:
Human immunodeficiency virus （HIV） is a retrovirusthat can lead to a condition in which the immune systembegins to fail， leading to opportunistic infections. HIV primarily infects vital cells in the humanimmune systemsuch as helper T cells（specifically CD4+ T cells）， macrophagesand dendritic cells. HIV infection leads to low levels of CD4+ T cells through thrHIV-1 gp120 is a non-glycosylated polypeptide chain， containing HIV-1 gp120 N-terminus immunodominant regions， 30-110 amino acids. The protein is fused to a six histidines tag. main mechanisms: firstly， direct viral killing of infected cells； secondly， increased rates of apoptosisin infected cells； and thirdly， killing of infected CD4+ T cells by CD8 cytotoxic lymphocytesthat recognize infected cells. When CD4+ T cell numbers decline below a critical level， cell-mediated immunityis lost， and the body becomes progressively more susceptible to opportunistic infections. HIV was classified as a member of the genus Lentivirus， part of the family of Retroviridae. Lentiviruses have many common morphologies and biological properties. Many species are infected by lentiviruses， which are characteristically responsible for long-duration illnesses with a long incubation period. Lentiviruses are transmitted as single-stranded， positive-sense， enveloped RNA viruses. Upon entry of the target cell， the viral RNA genomeis converted to double-stranded DNAby a virally encoded reverse transcriptasethat is present in the virus particle. This viral DNA is then integrated into the cellular DNA by a virally encoded integraseso that the genome can be transcribed. Once the virus has infected the cell， two pathways are possible: either the virus becomes latentand the infected cell continues to function， or the virus becomes active and replicates， and a large number of virus particles are liberated that can then infect other cells.

产品描述:
HIV-1 gp120 is a non-glycosylated polypeptide chain， containing HIV-1 gp120 N-terminus immunodominant regions， 30-110 amino acids. The protein is fused to a six histidines tag.
来源宿主:
大肠杆菌中重组表达

序列:


溶解建议:
提供的重组HIV-1 gp120 nef嵌合体蛋白产品为无菌的无色透明溶液形式.该产品已溶解在含25mM 磷酸钠和8M 尿素的10mM Tris-HCl缓冲液（pH 4.5）.

保存建议：
HIV-1 gp120 protein is shipped at ambient temperature. Upon arrival， Store at -20℃. Stable for Five years frozen. One month in solution at room temperature.
其他简介：

  ProSpec是一家全球著名细胞因子蛋白及相关抗体生产和研发品牌。ProSpec的生产和研发工厂位于以色列，专注于蛋白（重组及合成）生产研发，其独有的细菌和哺乳动物表达和蛋白折叠技术使其能在17年内成长为国际一流的科研级蛋白供应商。目前ProSpec可以提供细胞因子，生长因子，激素，信号蛋白，病毒抗原等近800种重组蛋白和100多种抗体，是世界上提供蛋白品种最多的公司之一，领先的生产工艺和规模使其可以提供毫克到克级蛋白，价格优于同类公司。绝大部分产品是天然成熟型蛋白，而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液，ProSpec-Tany绝大部分产品没有添加保护剂或盐，这就对工艺提出了更高的要求。同时，ProSpec-Tany绝大部分产品为冻干粉，因此易于运输和保存。
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