HIV-1 gp41

产品英文名称：
Recombinant HIV-1 gp41

英文简称:
HIV-1 gp41

中文名称:
重组HIV-1 gp41包膜蛋白

背景资料:
Human immunodeficiency virus （HIV） is a retrovirusthat can lead to a condition in which the immune systembegins to fail， leading to opportunistic infections. HIV primarily infects vital cells in the humanimmune systemsuch as helper T cells（specifically CD4+ T cells）， macrophagesand dendritic cells. HIV infection leads to low levels of CD4+ T cells through thrHIV-1 env gp41 Strain IIIB is a non-glycosylated 288 amino acids polypeptide chain （a.a. 466-753） having a molecular mass of 32kDa. The protein is fused to B-galactosidase （114 kDa） at the N- terminus. main mechanisms: firstly， direct viral killing of infected cells； secondly， increased rates of apoptosisin infected cells； and thirdly， killing of infected CD4+ T cells by CD8 cytotoxic lymphocytesthat recognize infected cells. When CD4+ T cell numbers decline below a critical level， cell-mediated immunityis lost， and the body becomes progressively more susceptible to opportunistic infections. HIV was classified as a member of the genus Lentivirus， part of the family of Retroviridae. Lentiviruses have many common morphologies and biological properties. Many species are infected by lentiviruses， which are characteristically responsible for long-duration illnesses with a long incubation period. Lentiviruses are transmitted as single-stranded， positive-sense， enveloped RNA viruses. Upon entry of the target cell， the viral RNA genomeis converted to double-stranded DNAby a virally encoded reverse transcriptasethat is present in the virus particle. This viral DNA is then integrated into the cellular DNA by a virally encoded integraseso that the genome can be transcribed. Once the virus has infected the cell， two pathways are possible: either the virus becomes latentand the infected cell continues to function， or the virus becomes active and replicates， and a large number of virus particles are liberated that can then infect other cells.

产品描述:
HIV-1 env gp41 Strain IIIB is a non-glycosylated 288 amino acids polypeptide chain （a.a. 466-753） having a molecular mass of 32kDa. The protein is fused to B-galactosidase （114 kDa） at the N- terminus.
来源宿主:
大肠杆菌中重组表达

序列:


溶解建议:
提供的重组HIV-1 gp41包膜蛋白产品为无菌的无色透明溶液形式.该产品已溶解在含8M 尿素和20mM 巯基乙醇溶液.

保存建议：
HIV-1 gp41 protein is shipped at ambient temperature. Upon arrival， Store at -20℃ Stable for Five years frozen. One month in solution at room temperature.
其他简介：

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