Exendin 4

产品英文名称：
Recombinant Exendin-4

英文简称:
Exendin 4

中文名称:
重组醋酸艾塞那肽

背景资料:
Exedin-4 Recombinant is a glucagon like peptide-1 receptor agonist. The native hormone is produced in the gut of Gila monster Heloderma suspectrum （a type of reptile found in the desert） that stimulates insulin production without causing threateningly low blood sugar， which can occur after using insulin and some anti-diabetes products. Recently， researchers used extracted saliva from gila monsters to create an unprecedented breakthrough in Diabetes Type 2 treatment. Unlike other products taken for type 2 diabetes， Exedin-4 has not bExendin-4 Recombinant is a novel 39-amino acids peptide having a molecular mass of 4186.7 Dalton， which shares 53%， sequence homology with GLP-17-36 amide and interacts with the same membrane receptor. The Exendin-4 is purified by proprietary chromatographic techniques.n linked with weight gain and actually resulted in weight loss， according to the researchers. Exedin-4 enhances glucose-dependant insulin secretion， suppresses inappropriately elevated glucagon secretion and slows gastric emptying in vivo. It also promotes B-cell proliferation and neogenesis in vitro and in animal models. Exedin-4 stimulates an increase in acinar cAMP， without stimulating the release of amylase.

产品描述:
Exendin-4 Recombinant is a novel 39-amino acids peptide having a molecular mass of 4186.7 Dalton， which shares 53%， sequence homology with GLP-17-36 amide and interacts with the same membrane receptor. The Exendin-4 is purified by proprietary chromatographic techniques.
来源宿主:
大肠杆菌中重组表达

序列:
His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser.

溶解建议:
提供的重组醋酸艾塞那肽产品为白色无菌冻干粉末，冻干之前是在4%甘露醇糖的20mM PBS缓冲液中透析过.推荐使用无菌的18MΩ的超纯水来溶解，浓度不低于100ug/ml，便于后续稀释.

保存建议：
Lyophilized Exendin Recombinant although stable at room temperature for 3 weeks， should be stored desiccated below -18℃. Upon reconstitution Exendin-4 should be stored at 4℃ between 2-7 days and for future use below -18℃. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）. Please prevent freeze-thaw cycles.
其他简介：

  ProSpec是一家全球著名细胞因子蛋白及相关抗体生产和研发品牌。ProSpec的生产和研发工厂位于以色列，专注于蛋白（重组及合成）生产研发，其独有的细菌和哺乳动物表达和蛋白折叠技术使其能在17年内成长为国际一流的科研级蛋白供应商。目前ProSpec可以提供细胞因子，生长因子，激素，信号蛋白，病毒抗原等近800种重组蛋白和100多种抗体，是世界上提供蛋白品种最多的公司之一，领先的生产工艺和规模使其可以提供毫克到克级蛋白，价格优于同类公司。绝大部分产品是天然成熟型蛋白，而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液，ProSpec-Tany绝大部分产品没有添加保护剂或盐，这就对工艺提出了更高的要求。同时，ProSpec-Tany绝大部分产品为冻干粉，因此易于运输和保存。
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