产品英文名称: Recombinant Human Dickkopf-Related Protein 2
英文简称: DKK2
中文名称: 重组人Dickkopf相关蛋白2(DDK2)
背景资料: Dickkopf-related protein 2 (DKK2) is a member of the dickkopf family, which has a vital role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In adults, Dkks are involved in bone formation and bone disease, cancer and Alzheimer disease. DKK2 contains 2 cysteine rich regions and is implicated in embryonic development through its interactions with the Wnt signaling pathway. DKK2 may function as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular environment and the presence of the co-factor kremen 2. DKK2 protein activity is also controlled by binding to the Wnt co-receptor LRP6 (LDL-receptor related protein 6).
产品描述: DKK2 Human Recombinant produced in E. coli is a single polypeptide chain containing 250 amino acids (34-259) and having a molecular mass of 27.6 kDa.DKK2 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
来源宿主: 大肠杆菌中重组表达