产品英文名称: Recombinant Human Phosphoethanolamine/Phosphocholine Phosphatase
英文简称: Phospho1
中文名称: 重组人磷酸氨基乙醇/磷酸胆碱磷酸酶
背景资料: PHOSPHO1 is involved in mineralization process & plays a role in bone and cartilage matrix mineralization.PHOSPHO1 is expressed at sites of mineralization in bone and cartilage. Highly expressed in osteoblast cell line SaOS-2 which produces a mineralized matrix.Orphan-1 is collagen type -2 is specific for cartilaginous tissues. Orphan1 is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces.Phosphoethanolamine(2-O3POCH2CH2NH3) is a key intermediate in the formation of cephalins, it is formed in liver and brain by phosphorylation of ethanolamine.PHOSPHO2 and PHOSPHO1 suMRGSHHHHHH GMASMSGCFP VSGLRCLSRD GRMAAQGAPR FLLTFDFDET IVDENSDDSI VRAAPGQRLP ESLRATYREG FYNEYMQRVF KYLGEQGVRP RDLSAIYEAI PLSPGMSDLL QFVAKQGACF EVILISDANT FGVESSLRAA GHHSLFRRIL SNPSGPDARG LLALRPFHTH SCARCPANMC KHKVLSDYLR ERAHDGVHFE RLFYVGDGAN DFCPMGLLAG GDVAFPRRGY PMHRLIQEAQ KAEPSSFRAS VVPWETAADV RLHLQQVLKSC.est subtle di大肠杆菌中重组表达erences in the charge distributions around the putative substrate entry site and in the location of potential H-bond donors.PHOSPHO1 exhibits high specific phosphoethanolamine and phosphocholine phosphatase activities PHOSPHO1 is a phosphatase enzyme for which expression is upregulated in mineralizing cells. PHOSPHO1 has b人磷酸氨基乙醇/磷酸胆碱磷酸酶重组蛋白是在大肠杆菌中重组表达的,是一条单链、非糖基化的多肽链,包含有295个氨基酸,分子量为31.3kDa.该人磷酸氨基乙醇/磷酸胆碱磷酸酶重组蛋白的N末端融合了His标签,该蛋白最终由标准的色谱技术纯化出.n implicated in the generation of Pi for matrix mineralization, a process central to skeletal development. PHOSPHO1 is a member of the haloacid dehalogenase(HAD) superfamily of Mg2+-dependent hydrolases. PHOSPHO1 exhibits high specific activities toward phosphoethanolamine(PEA) and phosphocholine(PCho).