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产品英文名称：
Recombinant Human Mitogen Activated Kinase Kinase 1

英文简称:
MEK1

中文名称:
重组人促分裂原活化蛋白激酶激酶1

背景资料:
MAP2K1 is a member of the dual specificity protein kinase family， which plays a role as a mitogen-activated protein （MAP） kinase kinase. MAP kinases， are recognized as extracellular signal-regulated kinases （ERKs）， that act as an integration position for multiple biochemical signals. MEK1 is located upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As a key player of MAP kinase signal transduction pathway， MEK1 is involved in many cellular processes such as proliferation， diSf9昆虫细胞中重组表达erentiation， transcription regulation and development. MAP2K1 catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a thr-glu-tyr sequence located in map kinases. MEK1 activates erk1 and erk2 map kinases.

产品描述:
MAP2K1 active Human Recombinant produced in Sf9 cells is a glycosylated， polypeptide chain containing amino acids 2-393 having a molecular mass of 47 kDa. MAP2K1 is fused to a polyhistidine tag and is purified by proprietary chromatographic techniques.
来源宿主:
Sf9昆虫细胞中重组表达

序列:


溶解建议:
提供的人促分裂原活化蛋白激酶激酶1（MEK1）产品为过滤灭菌的透明溶液；其中0.09mg/ml人促分裂原活化蛋白激酶激酶1（MEK1）产品溶解于40mM Tris，pH 8，0.15M NaCl，0.27M蔗糖，1mM DTT，0.2mM PMSF，1mM 苄眯，0.1mM 钒酸钠，0.03% Brij-35溶液中.

保存建议：
人促分裂原活化蛋白激酶激酶1（MEK1）溶液可以在4℃冷藏保存1-2周；如果想延长保存时间，建议分装后置于-20℃冻存.请避免反复冻融.
其他简介：

  ProSpec是一家全球著名细胞因子蛋白及相关抗体生产和研发品牌。ProSpec的生产和研发工厂位于以色列，专注于蛋白（重组及合成）生产研发，其独有的细菌和哺乳动物表达和蛋白折叠技术使其能在17年内成长为国际的科研级蛋白供应商。目前ProSpec可以提供细胞因子，生长因子，激素，信号蛋白，病毒抗原等近800种重组蛋白和100多种抗体，是世界上提供蛋白品种最多的公司之一，领先的生产工艺和规模使其可以提供毫克到克级蛋白，价格优于同类公司。绝大部分产品是天然成熟型蛋白，而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液，ProSpec-Tany绝大部分产品没有添加保护剂或盐，这就对工艺提出了更高的要求。同时，ProSpec-Tany绝大部分产品为冻干粉，因此易于运输和保存。