产品英文名称: Recombinant Human Thymus Expressed Chemokine (CCL25)
英文简称: TECK
中文名称: 重组人胸腺表达趋化因子
背景资料: CCL25 (Teck) is a novel CC chemokine, which is distantly related (about 20% amino acid sequence identity) to other CC chemokines. The mouse CCL25 cDNA has also b人胸腺表达趋化因子重组蛋白是在大肠杆菌中重组表达的,是一条单链、非糖基化的多肽链,包含有127个氨基酸,分子量为14.2kDa.该人胸腺表达趋化因子重组蛋白最终由标准的色谱技术纯化出.n cloned and shown to encode a 144 a.a. protein, which exhibits 49% a.a. sequence identity to the human CCL25. Human and mouse CCL25 expression was shown to be greatly restricted to the thymus and small intestine. While dendritic cells are identified as the source of CCL25 production in the thymus, dendritic cells derived from bone marrow do not express CCL25. CCL25 signals through the CCR9 receptor. Teck is possibly involved in T-cell development.Recombinant human and mouse Teck were shown to be chemotactic for activated macrophages, dendritic cells and thymocytes. The recombinant protein demonstrates chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritic cells but is inactive on peripheral blood lymphocytes and neutrophils.