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- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
- 英文名：
rMuCXCL3; C-X-C motif chemokine 3; Dendritic cell inflammatory protein 1; DCIP-1
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- 规格：
2 μg/10 μg/50 μg/100 μg
| 规格： | 2 μg | 产品价格： | ￥350.0 |
|---|---|---|---|
| 规格： | 10 μg | 产品价格： | ￥700.0 |
| 规格： | 50 μg | 产品价格： | ￥2000.0 |
| 规格： | 100 μg | 产品价格： | ￥3400.0 |
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
DCIP-1/CXCL3 Protein, Mouse
MCE 国际站：DCIP-1/CXCL3 Protein, Mouse
CXCL3 是中性粒细胞的趋化因子，属于 CXC 趋化因子亚家族。CXCL3 是一种分泌型生长因子，通过其同源受体 CXCR2 发出信号。CXCL3参与许多免疫反应，包括伤口愈合、癌症转移和血管生成。DCIP-1/CXCL3 Protein, Mouse 是在大肠杆菌中表达产生的，由 73 个氨基酸(A28-S100) 组成。
Synonyms: rMuCXCL3; C-X-C motif chemokine 3; Dendritic cell inflammatory protein 1; DCIP-1
Species: Mouse
Source: E. coli
Biological Activity: 1. Full biological activity determined by a chemotaxis bioassay using human CXCR2 transfected human 293 cells is in a concentration range of <100 ng/mL.
2. Measured in a cell proliferation assay using HUVEC human ureteral epithelial cell. The ED50 this effect is 1.747 ng/ml, corresponding to a specific activity is 5.724×105 units/mg.
研究背景：CXCL3 is also known as MIP-2 beta, or DCIP-1 in mouse, CINC2 in rat, and GRO-gamma in humans. CXCL3 is a member of the CXC chemokine subfamily, and it is subclassified as a Glu-Leu-Arg (ELR+) CXC chemokine. CXCL3 is originally identified in the supernatants of melanoma cell lines in culture, and is referred to as GRO (growth-related oncogene). Previous studies have reported that CXCL3 is produced by macrophages, osteoblasts, airway epithelium, dendritic cells, synovial fibroblasts, and cancers.
The amino acid sequence of human CXCL3 protein has low homology between mouse and rat CXCL3 protein.
CXCL3 plays an important role in leukocyte chemotaxis, angiogenesis, tumorigenesis, and cell invasion. CXCL3 exerts its functions through a number of signaling pathways including p38 MAPK, ERK1/2 MAPK and JAK2/STAT3 etc., by activating CXCR2 receptor. CXCL3 is highly expressed during the number of tumorous conditions including melanoma, prostate, colorectal, aggressive breast cancer tumors, hepatocellular carcinoma (HCC) and also during hepatic injury and inflammation.
The cancer types affected by the action of CXCL3 (along with CXCL1 and CXCL2) include prostate cancer, pancreatic cancer, melanoma, lung cancer, hepatocellular carcinoma, and gastric cancer. CXCL3 facilitates adipogenic differentiation through ERK- and JNK-induced induction of c/ebpb and c/ebpd by autocrine/paracrine manners in adipocytes. Furthermore, CXCL3 is also associated with vascular invasion and tumor capsule formation. CXCL3 plays a role in asthma severity and asthmatic airway remodeling.
蛋白编号：Q6W5C0 (A28-S100)
基因 ID：330122
产品分类：细胞因子和生长因子 | 趋化因子 | CXC 趋化因子 | 生长调节致癌基因 γ
Categories：Cytokines and Growth Factors | Chemokine & Receptors | CXC Chemokines | GRO-gamma
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