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- 详细信息
- 技术资料
- 抗体名：
组蛋白甲基化抗体
- 抗体英文名：
Anti-trimethyl-Histone H3 (Lys4) Antibody
- 供应商：
上海益启生物科技有限公司
- 克隆性：
多克隆
特点及优点：
• 源于Upstate品牌，推出全球ChIP验证级别抗体
• 提供超过1500种优质ChIP验证级别抗体
• 多种组蛋白ChIP验证抗体（06-559、05-665、
07-473、07-030）全球文献引用率第一
• 独家提供ChIP验证抗体套装含有阴性对照抗体和
PCR对照引物
简介：Histones are highly conserved proteins that serve as the structural scaffold for the organization of nuclear DNA into chromatin. Histone modifications regulate DNA transcription, repair, recombination, and replication. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which DNA is wrapped in repeating units, called nucleosomes, which limits DNA accessibility to the cellular machineries, which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Histone H3 contains a main globular domain and a long N-terminal tail and is involved with the structure of the nucleosomes of the 'beads on a string' structure. The N-terminal tail of histone H3 protrudes from the globular nucleosome core and can undergo several different types of epigenetic modifications that influence cellular processes. These modifications include the covalent attachment of methyl or acetyl groups to lysine and arginine amino acids and the phosphorylation of serine or threonine. H3K4me3 modifications are reported to occur consistently at transcription start sites and H3K4me3 domain is associated with higher transcription activity and cell identity in pre-implantation development and in the process of deriving embryonic stem cells from the inner cell mass and trophoblast stem cells from the trophectoderm. (Ref.: Liu, X., et al. (2016). Nature 537(7621); 558-562).
上海益启生物科技有限公司（简称：益启生物 , Shanghai Advantage Biological co .,Ltd 官方网站：www.shijihaocai.cn）公司正式于2015年成立，总部位于上海，从事生命科学领域的试剂耗材供应商，经过快速发展，成为MerckMillipore、SIGMA、Mpbio等国内外知名品牌的官方授权一级代理，保持良好的合作关系。客户主要覆盖华东地区科研和经销用户。
产品所涉及的研究领域涵盖免疫学、信号通路、肿瘤研究、细胞研究、药物筛选、干细胞研究、神经生物学、表观遗传学等等，为广大的科研研究用户提供完整解决方案。
曾获得代理品牌华东销售抗体精英奖、最佳市场开拓奖、最佳进步奖取得行业认可。
销售团队核心价值观：责任心、执行率、效率
公司使命：助力中国生命科学领域，为科研研究产业做贡献！
为员工创造美好事业和生活！与员工共同成长！
公司荣获奖项
2017年：MERCK公司授予我司2016年度最佳市场推广奖
2018年：MERCK公司授予我司2017年度最佳销售业绩奖
订购电话：021-33560585 13916378703 张经理
• 源于Upstate品牌，推出全球ChIP验证级别抗体
• 提供超过1500种优质ChIP验证级别抗体
• 多种组蛋白ChIP验证抗体（06-559、05-665、
07-473、07-030）全球文献引用率第一
• 独家提供ChIP验证抗体套装含有阴性对照抗体和
PCR对照引物
简介：Histones are highly conserved proteins that serve as the structural scaffold for the organization of nuclear DNA into chromatin. Histone modifications regulate DNA transcription, repair, recombination, and replication. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which DNA is wrapped in repeating units, called nucleosomes, which limits DNA accessibility to the cellular machineries, which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Histone H3 contains a main globular domain and a long N-terminal tail and is involved with the structure of the nucleosomes of the 'beads on a string' structure. The N-terminal tail of histone H3 protrudes from the globular nucleosome core and can undergo several different types of epigenetic modifications that influence cellular processes. These modifications include the covalent attachment of methyl or acetyl groups to lysine and arginine amino acids and the phosphorylation of serine or threonine. H3K4me3 modifications are reported to occur consistently at transcription start sites and H3K4me3 domain is associated with higher transcription activity and cell identity in pre-implantation development and in the process of deriving embryonic stem cells from the inner cell mass and trophoblast stem cells from the trophectoderm. (Ref.: Liu, X., et al. (2016). Nature 537(7621); 558-562).
上海益启生物科技有限公司（简称：益启生物 , Shanghai Advantage Biological co .,Ltd 官方网站：www.shijihaocai.cn）公司正式于2015年成立，总部位于上海，从事生命科学领域的试剂耗材供应商，经过快速发展，成为MerckMillipore、SIGMA、Mpbio等国内外知名品牌的官方授权一级代理，保持良好的合作关系。客户主要覆盖华东地区科研和经销用户。
产品所涉及的研究领域涵盖免疫学、信号通路、肿瘤研究、细胞研究、药物筛选、干细胞研究、神经生物学、表观遗传学等等，为广大的科研研究用户提供完整解决方案。
曾获得代理品牌华东销售抗体精英奖、最佳市场开拓奖、最佳进步奖取得行业认可。
销售团队核心价值观：责任心、执行率、效率
公司使命：助力中国生命科学领域，为科研研究产业做贡献！
为员工创造美好事业和生活！与员工共同成长！
公司荣获奖项
2017年：MERCK公司授予我司2016年度最佳市场推广奖
2018年：MERCK公司授予我司2017年度最佳销售业绩奖
订购电话：021-33560585 13916378703 张经理
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07-473 trimethyl-Histone H3 (Lys4)
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