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- 详细信息
- 询价记录
- 文献和实验
- 技术资料
- 保存条件:
-20℃ to -80℃
- 保质期:
12个月
- 英文名:
Recombinant Human SNCA / alpha-Synuclein Protein
- 库存:
99
- 供应商:
北京义翘神州科技股份有限公司
- 规格:
1.00 mg/100.00 µg/200.00 µg
| 规格: | 1.00 mg | 产品价格: | ¥12580.0 |
|---|---|---|---|
| 规格: | 100.00 µg | 产品价格: | ¥1920.0 |
| 规格: | 200.00 µg | 产品价格: | ¥2570.0 |
蛋白名称:Human SNCA / alpha-Synuclein Protein
蛋白构建:A DNA sequence encoding the mature form of human SNCA isoform 1 (P37840-1) (Met 1-Ala 140) was expressed and purified.
表达宿主:E. coli
蛋白纯度:> 90 % as determined by SDS-PAGE
蛋白活性:0
蛋白内毒素:Please contact us for more information.
预测N端:Met 1
蛋白分子量:The recombinant human SNCA consisting of 140 amino acids and has a calculated molecular mass of 14.5 kDa. It migrates as an approximately 19 kDa band in SDS-PAGE under reducing conditions.
蛋白NP号:P37840-1
蛋白氨基酸序列:Met1-Ala140
蛋白标签:Native
蛋白保存条件:Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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文献和实验2, Lin, H; et al. Exogenous Tetranectin Alleviates Pre-formed-fibrils-induced Synucleinopathies in SH-SY5Y Cells by Activating the Plasminogen Activation System. Neurochemical research, PMID: 35895152
3, Yan, YQ; et al. Different patterns of exosomal α-synuclein between Parkinson's disease and probable rapid eye movement sleep behavior disorder. European journal of neurology, PMID: 36047985
4, Wang, P; et al. α-Synuclein-carrying astrocytic extracellular vesicles in Parkinson pathogenesis and diagnosis. Translational neurodegeneration, PMID: 37620916
5, Yang, Y; et al. Calcium Influx: An Essential Process by which α-Synuclein Regulates Morphology of Erythrocytes. Journal of advanced research, PMID: 37714326
6, Yang, Y; et al. Erythrocytic α-Synuclein and the Gut Microbiome: Kindling of the Gut-Brain Axis in Parkinson's Disease. Movement disorders : official journal of the Movement Disorder Society, PMID: 37798868
7, Ahn, JS; et al. Real-time detection of Tau-381 protein using liquid crystal-based sensors for Alzheimer's disease diagnosis. Colloids and surfaces. B, Biointerfaces, PMID: 39260276
。 2. 亲和层析:rHuIFN-α2a粗提物用pH7.2,0.15mol/L PBS 透析过夜,上样于经pH7.2,0.15mol/L PBS平衡的亲和层析柱,流速0.5ml/分,然后用大量PBS流洗至流出液OD280≤0.02,再用pH2.4,0.1mol/L甘氨酸-HC1洗脱,洗脱液立即转至pH7.2,0.15mol/LPBS中透析过夜,测定蛋白浓度、纯度和活性。 三、保存方法 1. 亲和柱的再生:先后用10个柱床体积、含0.5mol/L
-synuclein)阳性包涵体为特征的少突胶质细胞变性,导致神经元髓鞘变性脱失,激活小胶质细胞,诱发氧化应激,进而导致神经元变性死亡。 图1. 中枢神经系统中神经胶质细胞的类型及与神经元之间的相互作用[1] 2.神经元本身 α-突触核蛋白异常聚集,造成神经元变性死亡。α-突触共核蛋白异常聚集的原因尚未明确,可能与遗传易感性和环境因素有关。 多系统萎缩主要症状 1. 自主神经功能障碍:往往是首发症状,常见的临床表现有尿失禁、尿频、尿急和尿潴留、男性勃起功能障碍、体位性低血压、吞咽困难、瞳孔
白细胞介素-2(interleukin rhlL-2,IL-2)主要由活化的T淋巴细胞分泌的一种糖蛋白,是调节机体免疫功能最主要的淋巴因子之一。天然IL-2含有糖基,基因重组IL-2不含糖基,由133个氨基酸组成,相对分子质量为15KD。IL-2在机体应答,免疫调节和抗肿瘤免疫中具有十分重要的作用。临床用于多种恶性实体肿瘤。重组人IL-2是一种重组人白细胞介素-2的生物制品,一般制备成粉针剂应用,其规格以活性单位而不是以重量单位标示。本研究拟通过双抗体放射免疫分析法又称为免疫沉淀法测定注射
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