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- 2025年08月12日
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100 µg
蛋白名称：Her2/ERBB2蛋白, Her2/ERBB2 protein
蛋白构建：A DNA sequence encoding the rat ErbB2 (AAH61863.1) extracellular domain (Met 4-Thr 656) was expressed, fused with a polyhistidine tag at the C-terminus.
表达宿主：HEK293 Cells
蛋白纯度：> 95 % as determined by SDS-PAGE
蛋白活性：0
蛋白内毒素：< 1.0 EU per μg of the protein as determined by the LAL method
预测N端：Thr 26
蛋白分子量：The recombinant rat ErbB2 comprises 642 amino acids and predicts a molecular mass of 71.3 kDa. The apparent molecular mass of the rat ErbB2 is approximately 110 kDa in SDS-PAGE under reducing conditions due to glycosylation.
蛋白NP号：AAH61863.1
蛋白氨基酸序列：Met4-Thr656
蛋白标签：C-His
蛋白保存条件：Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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文献和实验Assay for Isolation of Inhibitors of Her2-Kinase Expression
Her2 (ErbB2) protein is overexpressed in breast and other solid tumors, and its expression is associated with progressive disease. Current therapies directed toward Her2 either block dimerization of the receptor or inhibit tyrosine kinase
Automated Analysis of FISH-Stained HER2/neu Samples with Metafer
The HER2/neu gene (also known as ERBB2) is located on chromosome 17 (q11.2–q12) and encodes a glycoprotein known to be a member of the epidermal growth factor receptor family. Clinically, the determination of its amplification status
Her2为啥是ErbB信号通路的关键呢？因为没有她，就没法穿搭……
ErbB信号通路，是个做妇科肿瘤常见的信号通路，特别是乳腺癌研究中，对HER2的研究都很常见。为啥HER2（也就是ErbB2）的研究会这么多，这和ErbB信号通路本身是分不开的。我们先来看看ErbB信号通路是什么鬼？嗯，这个复杂程度，就有点令人发指了，不光是进入细胞后的内容丰富，膜受体也是特别复杂。夏老师给你们稍微简化一下，差不多就是这样：还是有点复杂，不是么？实际上，造成ErbB信号通路这么复杂的原因，主要就是ErbB信号通路的膜受体，一共有这么四种：ErbB1（也就是EGFR），ErbB2
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