anti-human IL-12/-23 (p40) mAb

产品名称：anti-human IL-12/-23 (p40) mAbs MT86/221, purified-anti-human IL-12/-23 (p40) mAbs MT86/221, purified

产品货号：3450-3-250

产品规格：250ug

应用类型：ELISpot, ELISA

保存建议：anti-human IL-12/-23 (p40) mAbs MT86/221, purified-anti-human IL-12/-23 (p40) mAbs MT86/221, purified建议收到产品后2-8°C保存，有效期为18个月。

背景资料：Interleukin-12 (IL-12, IL12) is, when biologically active, a heterodimer (p70) consisting of two covalently linked subunits, p35 and p40. IL-12 is produced by antigen-presenting cells, specifically dendritic cells and macrophages. IL-12 is a proinflammatory cytokine that promotes Th1-type responses by inducing IFN-γ production and enhancing proliferation and cytotoxicity of NK and T cells. Interleukin-23 (IL-23) is a disulfide-linked heterodimer which consists of a unique p19 subunit and the p40 subunit of IL-12. IL-23 is a proinflammatory cytokine, which is produced by macrophages and dendritic cells upon infections with certain pathogens. The IL-23 receptor is expressed on Th17 cells and IL-23 is responsible for Th17 expansion and stabilization. Since both IL-12 and IL-23 heterodimers comprise the p40 subunit, capture immunoassays based on antibodies to p40 will detect both cytokines. Such assays can also detect p40 monomers and dimers.

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关键词：anti-human IL-12/-23 (p40) mAbs MT86/221, purified，anti-human IL-12/-23 (p40) mAbs MT86/221, purified， IL-12/-23（p40）mAbs MT86/221