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- 文献和实验
- 技术资料
- 免疫原:
加了半胱氨酸的人 p38合成肽, 长20 AA, 钥孔虫戚血蓝素螯合.
- 抗体英文名:
p38 Antibody: PE/ATTO 594
- 规格:
100ul
产品名称:p38 抗体:偶联PE/ATTO 594-p38 Antibody: PE/ATTO 594
产品货号:SPC-172D-P594 产品规格:100ul 应用类型:WB | IHC | ICC/IF | IP
保存建议:p38 抗体:偶联PE/ATTO 594-p38 Antibody: PE/ATTO 594厂家推荐蓝冰运输。收到产品后建议保存于-20ºC。
背景资料:The MAPK (mitogen activated protein kinase) comprises a family of ubiquitous praline-directed, protein-serine/threonine kinases which signal transduction pathways that control intracellular events including acute responses to hormones and major developmental changes in organisms (1). This super family consists of stress activated protein kinases (SAPKs); extracellular signal-regulated kinases (ERKs); and p38 kinases, each of which forms a separate pathway (2). The kinase members that populate each pathway are sequentially activated by phosphorylation. Upon activation, p38 MAPK/SAPK2a translocates into the nucleus where it phosphorylates one or more nuclear substrates, effecting transcriptional changes and other cellular processes involved in cell growth, division, differentiation, inflammation, and death (3). Specifically p38 always acts as a pro-apoptotic factor with its activation leading to the release of cytochrome c from mitochondria and cleavage of caspase 3 and its downstream effector, PARP (4). p38 MAPK is activated by a variety of chemical stress inducers including hydrogen peroxide, heavy metals, anisomycin, sodium salicylate, LPS, and biological stress signals such as tumor necrosis factor, interleukin-1, ionizing and UV irradiation, hyperosmotic stress and chemotherapeutic drugs (5). As a result, p38 alpha has been widely validated as a target for inflammatory disease including rheumatoid arthritis, COPD and psoriasis (6) and has also been implicated in cancer, CNS and diabetes (7).
点击:p38 抗体:偶联PE/ATTO 594-p38 Antibody: PE/ATTO 594查看更详细产品说明,更多应用、储存、价格、货期等信息请致电400-6800-868垂询StressMarq中国区域授权总代理艾美捷科技有限公司。更多特色试剂盒、特色抗体以及特色试剂等产品评论,请点击查看每日生物评论网站。
StressMarq Biosciences Inc. 在2007年成立于加拿大维多利亚,是一家生物科技公司,专门从事试剂与试剂盒研究,服务范围遍及全球50多个国家。 StressMarq公司的核心技术领域为细胞应激(尤其是热休克蛋白(HSP)领域,领先全球),离子通道,载体研究,同时在神经科学领域推出特有的具有生物活性的Tau蛋白与a-突触核蛋白。产品领域涉及到:细胞凋亡、细胞信号、通路和转运、细胞器标志物、热休克、神经生物学、神经科学、氧化应激、磷酸化运输等。除了提供用于进一步研究的相关工具外,StressMarq还提供全新的尖端研究工具,用于开发新的生物项目,包括全球独特的a B晶体蛋白ELISA试剂盒(现在是公认的乳腺癌标志物);热休克同源蛋白70(Hsc70)ELISA试剂盒;以及用于神经衰退研究的Tau活性蛋白与a-突触核蛋白。本公司已将专业技术扩展到抗体、小分子离子通道与载体等更新领域,前者包括当前热门的核心领域:Nav、Cav、TRP、Kv、KCNQ、HCN,后者包括当前热门的核心领域:ENaC、NCC和NKCC2以及主要水通道蛋白载体。
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关键词:p38 Antibody: PE/ATTO 594,p38 抗体:偶联PE/ATTO 594,p38
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文献和实验保持优异的水溶性,为该波段最亮的橙色荧光染料。例如:同等的标记程度下,CF543 标记的羊抗鼠IgG抗体的亮度高于用Alexa Fluor 546 标记的2~10倍。CF 555、AlexaFluor 555、Tetramethylrhodamine(TAMRA) 等匹配Cy3滤光片的橙色荧光染料;红色(568-594nm处激发)CF 568、Alexa Fluor® 568,ATTO 565, Rhodamine Red等568nm处红色荧光染料;CF 568染料耐光性最好;高效水溶
kinase is KIR 3.1 and have developed a phospho-selective antibody against the Y12 motif of this channel. Much like KOR and p38 MAP kinase, phosphorylation of this potassium channel increases following repeated stress. The following chapter discusses
【求助】急急求助答案——关于SB203580抑制P38MAPK的自身磷酸化
3/6 may contribute to the basal level of p38 MAPK activation that is independent of AL-LC–triggered p38 MAPK phosphorylation.” 在加上楼主的那一段: “Using immunoprecipitation of TAB1 with TAB1-specific antibody from total cell lysate followed by immunoblotting
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