溶酶体相关膜蛋白2 抗体：偶联HRP|LAMP2 Antib

产品名称：溶酶体相关膜蛋白2 抗体：偶联HRP-LAMP2 Antibody: HRP

产品货号：SMC-141D-HRP

产品规格：100ug

应用类型：WB | ICC/IF | IP

保存建议：溶酶体相关膜蛋白2 抗体：偶联HRP-LAMP2 Antibody: HRP厂家推荐蓝冰运输。收到产品后建议保存于-20ºC。

背景资料：Lysosme associated membrane proteins, or LAMP1 and LAMP2, are major constituents of the lysosomal membrane. The two have closely related structures, with 37% sequence homology (2). They are both transmembrane glycoproteins that are localized primarily in lysosomes and late endosomes. Newly synthesized molecules are mostly transported from the trans-Golgi network directly to endosomes and then to lysosomes. A second pathway involves the lamps being delivered from the Golgi to the cell surface, and then along the endocytic pathway to the lysosomes. A minor pathway involves transport via the plasma membrane (3).LAMP2 has also been detected at the plasma membrane of cells, as well as in cells that secrete lysosomal hydrolases. A study in the developmental expresses patterns of membrane LAMP2 transcripts indicate a possible involvement of this protein in cell-cell or cell-extracellular matrix interaction, and appear to reflect tissue and cell type specific roles of lysosomes during morphogenesis (4). Upon stimulation, a rapid translocation of intracellular LAMPs to the cell membrane is dependent on a carboxyl-terminal tyrosine based motif (YXXI) (5). This stimulation has also been shown to have an associated release of histamine, leukotriene C 9$) and prostaglandin D 9@), which shows that LAMP1 and LAMP2 are activation markers for normal mast cells (5). They have also been linked to the inflammatory response in that they promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, and therefore possibly the adhesion of PBMC to the site of inflammation (6). LAMP2 has also been shown to be critical for autophagy, in conversion of early autophagic vacuoles to vacuoles which rapidly degrade their content (7).

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StressMarq Biosciences Inc. 在2007年成立于加拿大维多利亚，是一家生物科技公司，专门从事试剂与试剂盒研究，服务范围遍及全球50多个国家。 StressMarq公司的核心技术领域为细胞应激（尤其是热休克蛋白（HSP）领域，领先全球），离子通道，载体研究，同时在神经科学领域推出特有的具有生物活性的Tau蛋白与a-突触核蛋白。产品领域涉及到：细胞凋亡、细胞信号、通路和转运、细胞器标志物、热休克、神经生物学、神经科学、氧化应激、磷酸化运输等。除了提供用于进一步研究的相关工具外，StressMarq还提供全新的尖端研究工具，用于开发新的生物项目，包括全球独特的a B晶体蛋白ELISA试剂盒（现在是公认的乳腺癌标志物）；热休克同源蛋白70（Hsc70）ELISA试剂盒；以及用于神经衰退研究的Tau活性蛋白与a-突触核蛋白。本公司已将专业技术扩展到抗体、小分子离子通道与载体等更新领域，前者包括当前热门的核心领域：Nav、Cav、TRP、Kv、KCNQ、HCN，后者包括当前热门的核心领域：ENaC、NCC和NKCC2以及主要水通道蛋白载体。

艾美捷科技有限公司品线覆盖生物研究各个领域，主要包括：分子生物学（核酸蛋白研究工具、cDNA/RNA、转染试剂、植物组培/细胞培养、生化试剂及试剂盒），试剂（蛋白酶抑制剂、化合物、荧光染料/探针、动物血清）、抗体（一抗、二抗、封闭血清）， 蛋白及试剂盒（细胞因子/重组蛋白、细胞凋亡/代谢/损伤、表观遗传、天然免疫）等。艾美捷为您寻找并提供最优的产品解决方案、最完备的物流服务、最及时的售后服务。如果您对上述产品线感兴趣，请致电免费服务热线到艾美捷垂询相关产品信息及完整实验解决方案。

关键词：LAMP2 Antibody: HRP，溶酶体相关膜蛋白2 抗体：偶联HRP，LAMP2