Anti-CACNB4 antibody

Anti-CACNB4 antibody

Cat. No.     JC263359
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-CACNB4 rabbit polyclonal antibody
Applications        ELISA, IHC 
Immunogen               Synthetic peptide of human CACNB4
Reactivity                 Human, Mouse
Content                     0.5 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification

Target information
Symbol                 CACNB4
Full name                 calcium voltage-gated channel auxiliary subunit beta 4
Synonyms    EA5; EJM; CAB4; EIG9; EJM4; EJM6; CACNLB4
Swissprot    O00305

Target Background
This gene encodes a member of the beta subunit family of voltage-dependent calcium channel complex proteins. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. The protein encoded by this locus plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy (IGE) and juvenile myoclonic epilepsy (JME). Multiple transcript variants encoding different isoforms have been found for this gene.

Anti-CACNB4 antibody
Applications
Immunohistochemistry
Predicted cell location: Cytoplasm and Nucleus
Positive control: Human thyroid cancer
Recommended dilution: 25-100    Predicted cell location: Cytoplasm and Nucleus
Positive control: Human tonsil
Recommended dilution: 25-100