Anti-VPS4A antibody

Anti-VPS4A antibody

Cat. No.     JC262482
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-VPS4A rabbit polyclonal antibody
Applications        ELISA, WB, IHC 
Immunogen               Synthetic peptide of human VPS4A
Reactivity                 Human, Mouse, Rat
Content                     0.5 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification

Target information
Symbol                 VPS4A
Full name                 vacuolar protein sorting 4 homolog A (S. cerevisiae)
Synonyms    SKD1; SKD2; VPS4; SKD1A; VPS4-1
Swissprot    Q9UN37

Target Background
The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. The mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be really an yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 16; the gene for the other resides on chromosome 18.

Anti-VPS4A antibody
Applications
Immunohistochemistry
Predicted cell location: Cytoplasm and Cell membrane
Positive control: Human liver cancer
Recommended dilution: 25-100    Predicted cell location: Cytoplasm and Cell membrane
Positive control: Human thyroid cancer
Recommended dilution: 25-100