Anti-TNFRSF13C antibody

Anti-TNFRSF13C antibody

Cat. No.  JC261957
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-TNFRSF13C rabbit polyclonal antibody
Applications        ELISA, IHC 
Immunogen               Synthetic peptide of human TNFRSF13C
Reactivity                 Human, Mouse
Content                     0.7 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification

Target information
Symbol                 TNFRSF13C
Full name                 tumor necrosis factor receptor superfamily, member 13C
Synonyms    BAFFR; CD268; CVID4; BAFF-R; BROMIX; prolixin
Swissprot    Q96RJ3

Target Background
B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival.

Anti-TNFRSF13C antibody
Applications
Immunohistochemistry
Predicted cell location: Cytoplasm
Positive control: Human colon cancer
Recommended dilution: 50-200