sigma试剂-阿卡地新

阿卡地新

AICAR

≥98% (HPLC), powder

别名: 5-氨基咪唑-4-羧酰胺-1-β-D-呋喃甲苷, N¹-(β-D-核糖呋喃甲酰)-5-氨基咪唑-4-羧酰胺, 阿卡地新

General description

Adenosine monophosphate protein kinase (AMPK) activator 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) modulates cellular energy. It regulates lipid and glucose metabolism, pro-inflammatory responses, cytokine production, cell proliferation and apoptosis. AICAR improves ischemia or reperfusion injury and kidney fibrosis in rats. It provides protection against acute tubular necrosis.

Application

AICAR has been used to provide protection against cisplatin-induced acute kidney injury through the JAK (tyrosine-protein kinase )/STAT (signal transducer and activator of transcription )/SOCS (suppressor of cytokine signaling) pathway. It also has been used in the assay of FapR (malonyl-CoA responsive bacterial transcriptional factor )-NLuc (nanoLuciferase) biosensor activity.

包装

5, 25 mg in glass bottle

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