Product overview
Description Anti-SCNN1A rabbit polyclonal antibody
Applications ELISA, IHC
Immunogen Synthetic peptide of human SCNN1A
Reactivity Human
Content 0.3 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information
Symbol SCNN1A
Full name sodium channel, non-voltage-gated 1 alpha subunit
Synonyms BESC2; ENaCa; SCNEA; SCNN1; ENaCalpha
Swissprot P37088
Target Background
Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the alpha subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), a rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Anti-SCNN1A antibody Applications
Immunohistochemistry
Predicted cell location: Cytoplasm
Positive control: Human thyroid cancer
Recommended dilution: 25-100 Predicted cell location: Cytoplasm
Positive control: Human colon cancer
Recommended dilution: 25-100