Product overview
Description Anti-SOCS1 rabbit polyclonal antibody
Applications ELISA, WB, IHC
Immunogen Synthetic peptide of human SOCS1
Reactivity Human, Mouse, Rat
Content 0.7 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Anti-SOCS1 antibody Target information
Symbol SOCS1
Full name Suppressor of cytokine signaling 1
Synonyms JAB, CIS1, SSI1, TIP3, CISH1, SSI-1, SOCS-1
Swissprot O15524
Target Background
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival.
Anti-SOCS1 antibody Applications
Immunohistochemistry
Predicted cell location: Cytoplasm
Positive control: Human ovarian cancer
Recommended dilution: 50-200 Predicted cell location: Cytoplasm
Positive control: Human gastric cancer
Recommended dilution: 50-200