Product overview
Description Anti-ADRBK1 rabbit polyclonal antibody
Applications ELISA, IHC
Immunogen Synthetic peptide of human ADRBK1
Reactivity Human, Mouse, Rat
Content 0.5 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information
Symbol ADRBK1
Full name adrenergic, beta, receptor kinase 1
Synonyms GRK2, BARK1, BETA-ARK1
Swissprot P25098
Target Background
The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart.
Anti-ADRBK1 antibody Applications
Immunohistochemistry
Predicted cell location: Cytoplasm
Positive control: Human thyroid cancer
Recommended dilution: 100-300