Anti-Cdc42/RhoA/Rac1 antibody

Anti-Cdc42/RhoA/Rac1 antibody

Cat. No.     JC260059
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-Cdc42/RhoA/Rac1 rabbit polyclonal antibody
Applications        ELISA, WB 
Immunogen               Synthetic peptide of human Cdc42/RhoA/Rac1
Reactivity                 Human, Mouse, Rat
Content                     0.3 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification

Target information
Symbol                 Cdc42
Full name                 Cell division cycle 42
Synonyms    TKS; G25K; CDC42Hs
Swissprot    P60953

Target Background
The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3, 4, 5, 7, 8 and 20.

Anti-Cdc42/RhoA/Rac1 antibody
Applications
Western blotting
Predicted band size:23 kDa
Positive control:Human fetal brain tissue 
Recommended dilution: 200-1000