PRKAB1 | AMPK beta-1 Mouse mAb(bsm-33426M)-50ul/100ul/200ul/200ug产品图
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PRKAB1 | AMPK beta-1 Mouse mAb

(bsm-33426M)-50ul/100ul/200ul/200ug
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  • bsm-33426M
  • 2026年10月14日
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    北京博奥森生物技术有限公司
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    • 规格：

      50ul/100ul/200ul/200ug

    规格：50ul产品价格：￥1180.0
    规格：100ul产品价格：￥1980.0
    规格：200ul产品价格：￥2800.0
    规格：200ug产品价格：￥5600.0
    产品编号bsm-33426M
    英文名称AMPK b1 Mouse mAb
    中文名称腺苷单磷酸活化蛋白激酶β1单克隆抗体
    英文别名5 AMP activated protein kinase subunit beta 1; AMPK; AMPK beta 1 chain; AMPKb; HAMPKb; PRKAB1; 5'-AMP-activated protein kinase subunit beta-1; AMP-activated protein kinase beta subunit; protein kinase, AMP-activated, noncatalytic, beta-1; AMPK beta-1 chain; 5'-AMP-activated protein kinase beta-1 subunit; AMPKb; AMPK subunit beta-1; AAKB1_HUMAN; AMPK b1; AMPK-b1.
    产品应用WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    交叉反应Human, Mouse, Rat
    抗体来源Mouse
    免疫原Recombinant human AMPK b1 Protein
    亚型IgG1
    性状Liquid
    纯化方法affinity purified by Protein A
    克隆类型Monoclonal
    理论分子量30 kDa
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Cancer > Cancer Metabolism > Metabolic signaling pathway > Integration of energy metabolism

    Cardiovascular > Lipids / Lipoproteins > Fatty Acids > Metabolism

    Metabolism > Pathways and Processes > Metabolic signaling pathways > Energy transfer pathways > Integration of energy

    Metabolism > Pathways and Processes > Metabolic signaling pathways > Lipid and lipoprotein metabolism > Fatty acids

    Metabolism > Pathways and Processes > Redox metabolism > Fatty acid oxidation

    Metabolism > Types of disease > Cancer

    Signal Transduction > Metabolism > Lipid metabolism

    Signal Transduction > Signaling Pathway > Lipid Signaling > Lipid Kinases

    亚基AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2.
    组织特异性Highly expressed in kidney, heart, white adipose tissue, lung and spleen.
    翻译后修饰Phosphorylated when associated with the catalytic subunit (PRKAA1 or PRKAA2). Phosphorylated by ULK1; leading to negatively regulate AMPK activity and suggesting the existence of a regulatory feedback loop between ULK1 and AMPK.
    相似性Belongs to the 5'-AMP-activated protein kinase beta subunit family.
    功能Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta‌‌-Methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex. [provided by RefSeq, Jul 2008].

     

    应用推荐稀释比例
    {WB}{1:500-2000}
    {IHC-P}{1:100-500}
    {IHC-F}{1:100-500}
    {IF}{1:100-500}

     

    产品细节图片1
    Sample:
    _x000D_ Cerebrum (Mouse) Lysate at 40 ug
    _x000D_ Cerebrum (Rat) Lysate at 40 ug
    _x000D_ U87MG(Human) Cell Lysate at 30 ug
    _x000D_ U251(Human) Cell Lysate at 30 ug
    _x000D_ Primary: Anti- AMPK b1 (bsm-33426M) at 1/1000 dilution
    _x000D_ Secondary: IRDye800CW Goat Anti-Mouse IgG at 1/20000 dilution
    _x000D_ Predicted band size: 30 kD
    _x000D_ Observed band size: 38 kD
    产品细节图片2
    Sample:
    _x000D_ Cerebrum (Rat) Lysate at 40 ug
    _x000D_ Primary: Anti- AMPK b1 (bsm-33426M) at 1/1000 dilution
    _x000D_ Secondary: IRDye800CW Goat Anti- Mouse IgG at 1/20000 dilution
    _x000D_ Predicted band size: 30 kD
    _x000D_ Observed band size: 38 kD
    _x000D_
    产品细节图片3
    P‌‌araformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (AMPK b1) Monoclonal Antibody, Unconjugated (bsm-33426M) at 1:800 overnight at 4°C, followed by operating according to SP Kit(Mouse) (sp-0024) instructions and DAB staining.

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    图标文献和实验
    该产品被引用文献

    [IF=7.129] Xing Guo. et al. Microcystin leucine arginine induces human sperm damage: Involvement of the Ca2+/CaMKKβ/AMPK pathway. ECOTOX ENVIRON SAFE. 2023 May;256:114845 WB Human

    [IF=5.811] Han Xue. et al. Protective Effects of 6-Gingerol on Cardiotoxicity Induced by Arsenic Trioxide Through AMPK/SIRT1/PGC-1α Signaling Pathway. FRONT PHARMACOL. 2022 Apr;0:1298 WB Mouse

    [IF=5.1] Lei Wu. et al. Flavonoids of Mao Jian Green Tea Ameliorate Glycemic Metabolism in Type-2-Diabetic Rats via AMPK Signaling Pathways and Gut Microbiota Regulation. FOODS. 2025 Jul;14(13):2402 WB Rat

    [IF=2.843] Lili Jin. et al. A synthetic peptide AWRK6 ameliorates metabolic associated fatty liver disease: involvement of lipid and glucose homeostasis. Peptides. 2021 Sep;143:170597 WB Mouse

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    文献支持
    PRKAB1 | AMPK beta-1 Mouse mAb(bsm-33426M)-50ul/100ul/200ul/200ug
    ￥1180 - 5600