Product overview
Description Anti-BAG3 rabbit polyclonal antibody
Applications ELISA, WB, IHC
Immunogen Fusion protein of human BAG3
Reactivity Human, Mouse
Content 0.6 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Anti-BAG3 antibody Target information
Symbol BAG3
Full name BCL2 associated athanogene 3
Synonyms BIS; MFM6; BAG-3; CAIR-1
Swissprot O95817
Target Background
BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner.
Anti-BAG3 antibody Applications
Immunohistochemistry
Predicted cell location: Cytoplasm or Nucleus
Positive control: Human cervical cancer
Recommended dilution: 40-200 Predicted cell location: Cytoplasm or Nucleus
Positive control: Human colorectal cancer
Recommended dilution: 40-200