Product overview
Description Anti-HIF1A rabbit polyclonal antibody
Applications ELISA, WB
Immunogen Synthetic peptide of human HIF1A
Reactivity Human, Mouse, Rat
Content 0.6 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information
Symbol HIF1A
Full name hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
Synonyms HIF1; MOP1; PASD8; HIF-1A; bHLHe78; HIF-1alpha; HIF1-ALPHA
Swissprot Q16665
Target Background
This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease.
Anti-HIF1A antibody Applications
Western blotting
Predicted band size:93 kDa
Positive control:293T cells untreated and treated with cobalt chloride (0.1 mM for 4 hours)
Recommended dilution: 500-2000