Product overview
Description Anti-ATRX rabbit polyclonal antibody
Applications ELISA, IHC
Immunogen Synthetic peptide of human ATRX
Reactivity Human, Mouse
Content 0.5 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Anti-ATRX antibody Target information
Symbol ATRX
Full name ATRX, chromatin remodeler
Synonyms JMS; SHS; XH2; XNP; ATR2; SFM1; MRX52; RAD54; MRXHF1; RAD54L; ZNF-HX
Swissprot P46100
Target Background
The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Mutations in this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.
Anti-ATRX antibody Applications
Immunohistochemistry
Predicted cell location: Nucleus
Positive control: Human colorectal cancer
Recommended dilution: 25-100 Predicted cell location: Nucleus
Positive control: Human ovarian cancer
Recommended dilution: 25-100