Product overview
Description Anti-DKK1 rabbit polyclonal antibody
Applications ELISA, IHC
Immunogen Synthetic peptide of human DKK1
Reactivity Human, Mouse
Content 0.8 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information
Symbol DKK1
Full name dickkopf WNT signaling pathway inhibitor 1
Synonyms SK; DKK-1
Swissprot O94907
Target Background
This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma.