Product overview
Description Anti-RAF1 rabbit polyclonal antibody
Applications ELISA, WB, IHC
Immunogen Fusion protein of human RAF1
Reactivity Human, Mouse, Rat
Content 0.6 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information
Symbol RAF1
Full name Raf-1 proto-oncogene, serine/threonine kinase
Synonyms NS5; CRAF; Raf-1; c-Raf; CMD1NN
Swissprot P04049
Target Background
This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration.