Product overview
Description Anti-MERTK rabbit polyclonal antibody
Applications ELISA, IHC
Immunogen Fusion protein of human MERTK
Reactivity Human, Mouse, Rat
Content 0.4 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information
Symbol MERTK
Full name c-mer proto-oncogene tyrosine kinase
Synonyms MER, RP38, c-mer
Swissprot Q12866
Target Background
This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP).