Product overview
Description Anti-CTNNA1 rabbit polyclonal antibody
Applications ELISA, IHC
Immunogen Fusion protein of human CTNNA1
Reactivity Human, Mouse
Content 0.1 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information
Symbol CTNNA1
Full name Catenin (cadherin-associated protein), alpha 1, 102kDa
Synonyms CAP102
Swissprot P35221
Target Background
Catenin alpha-1 is a protein that in humans is encoded by the CTNNA1 gene. Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components.