Product overview
Description Anti-NF1 rabbit polyclonal antibody
Applications ELISA, WB, IHC
Immunogen Synthetic peptide of human NF1
Reactivity Human, Mouse, Rat
Content 0.5 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information
Symbol NF1
Full name neurofibromin 1
Synonyms WSS; NFNS; VRNF
Swissprot P21359
Target Background
This gene product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA>UGA->Arg1306Term) resulting in premature translation termination. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene.
Anti-NF1 antibody Applications
Immunohistochemistry
Predicted cell location: Cytoplasm
Positive control: Human breast cancer
Recommended dilution: 20-100