Product overview
Description Anti-CALD1 rabbit polyclonal antibody
Applications ELISA, IHC
Immunogen Fusion protein of human CALD1
Reactivity Human, Rat
Content 0.5 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information
Symbol CALD1
Full name caldesmon 1
Synonyms CDM, HCAD, LCAD, H-CAD, L-CAD, NAG22
Swissprot Q05682
Target Background
This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.