Product overview Description Anti-ELAC2 rabbit polyclonal antibody
Applications ELISA, WB
Immunogen Fusion protein of human ELAC2
Reactivity Human, Mouse, Rat
Content 0.7 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information Symbol ELAC2
Full name elaC ribonuclease Z 2
Synonyms ELC2; HPC2; COXPD17
Swissprot Q9BQ52
Target Background The protein encoded by this gene has a C-terminal domain with tRNA 3′ processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
Applications Western blotting
Predicted band size:92 kDa
Positive control:A375 and LoVo cells, human testis tissue and Hela cells
Recommended dilution: 500-2000