Product overview Description Anti-DMRT3 rabbit polyclonal antibody
Applications ELISA, WB, IHC
Immunogen Fusion protein of human DMRT3
Reactivity Human, Mouse, Rat
Content 0.5 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information Symbol DMRT3
Full name doublesex and mab-3 related transcription factor 3
Synonyms DMRTA3
Swissprot Q9NQL9
Target Background The DMRT (doublesex and mab-3 related transcription factor) genes encode a large family of transcription factors that are related to the Drosophila doublesex proteins. Expressed primarily in the gonads, DMRT proteins contain cysteine-rich DNA-binding motifs and are thought to play an important role in sexual development. DMRT3 (doublesex and mab-3 related transcription factor 3), also known as DMRTA3, is a 472 amino acid protein that contains one DM DNA-binding domain and belongs to the DMRT family. Localized to the nucleus, DMRT3 is expressed specifically in testis and is thought to regulate transcriptional events during early sexual development. The gene encoding DMRT3 maps to human chromosome 9, which houses over 900 genes and comprises nearly 4% of the human genome. Hereditary hemorrhagic telangiectasia, which is characterized by harmful vascular defects, and Familial dysautonomia, are both associated with chromosome 9. Notably, chromosome 9 encompasses the largest interferon family gene cluster.
Applications Immunohistochemistry
Predicted cell location: Cytoplasm
Positive control: Human ovarian cancer
Recommended dilution: 100-300 Predicted cell location: Cytoplasm
Positive control: Human breast cancer
Recommended dilution: 100-300