Anti-CDKN1A antibody

Anti-CDKN1A antibody


Cat. No.     JK220091
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-CDKN1A rabbit polyclonal antibody
Applications        ELISA, IHC 
Immunogen               Fusion protein of human CDKN1A
Reactivity                 Human
Content                     0.4 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification

Target information
Symbol                 CDKN1A
Full name                 cyclin-dependent kinase inhibitor 1A (p21, Cip1)
Synonyms    P21; CIP1; SDI1; WAF1; CAP20; CDKN1; MDA-6; p21CIP1
Swissprot    P38936

Target Background
This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for this gene.