Anti-JAM3 antibody

Anti-JAM3 antibody


Cat. No.     JK164303
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-JAM3 rabbit polyclonal antibody
Applications        ELISA, IHC 
Immunogen               Synthetic peptide of human JAM3
Reactivity                 Human, Mouse
Content                     1.08 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification

Target information
Symbol                 JAM3
Full name                 junctional adhesion molecule 3
Synonyms    JAMC; JAM-2; JAM-3; JAM-C
Swissprot    Q9BX67

Target Background
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. Unlike other proteins in this family, the this protein is unable to adhere to leukocyte cell lines and only forms weak homotypic interactions. The encoded protein is a member of the junctional adhesion molecule protein family and acts as a receptor for another member of this family. A mutation in an intron of this gene is associated with hemorrhagic destruction of the brain, subependymal calcification, and congenital cataracts. Alternative splicing results in multiple transcript variants.