Product overview
Description Anti-GFI1 rabbit polyclonal antibody
Applications ELISA, IHC
Immunogen Synthetic peptide of human GFI1
Reactivity Human, Mouse, Rat
Content 1.62 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information
Symbol GFI1
Full name growth factor independent 1 transcriptional repressor
Synonyms SCN2; GFI-1; GFI1A; ZNF163
Swissprot Q99684
Target Background
This gene encodes a nuclear zinc finger protein that functions as a transcriptional repressor. This protein plays a role in diverse developmental contexts, including hematopoiesis and oncogenesis. It functions as part of a complex along with other cofactors to control histone modifications that lead to silencing of the target gene promoters. Mutations in this gene cause autosomal dominant severe congenital neutropenia, and also dominant nonimmune chronic idiopathic neutropenia of adults, which are heterogeneous hematopoietic disorders that cause predispositions to leukemias and infections. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene.