Product overview
Description Anti-CHFR rabbit polyclonal antibody
Applications ELISA, WB, IHC
Immunogen Synthetic peptide of human CHFR
Reactivity Human
Content 0.3 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information
Symbol CHFR
Full name checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase
Synonyms RNF116; RNF196
Swissprot Q96EP1
Target Background
This gene encodes an E3 ubiquitin-protein ligase required for the maintenance of the antephase checkpoint that regulates cell cycle entry into mitosis and, therefore, may play a key role in cell cycle progression and tumorigenesis. The encoded protein has an N-terminal forkhead-associated domain, a central RING-finger domain, and a cysteine-rich C-terminal region. Alternatively spliced transcript variants that encode different protein isoforms have been described.