Anti-NFATC1 antibody

Anti-NFATC1 antibody

Cat. No.     JC221028
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-NFATC1 rabbit polyclonal antibody
Applications        ELISA, IHC 
Immunogen               Fusion protein of human NFATC1
Reactivity                 Human, Mouse
Content                     0.2 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification

Target information
Symbol                 NFATC1
Full name                 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
Synonyms    NFAT2, NFATc, NF-ATC
Swissprot    O95644

Target Background
The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Five transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes.

Applications
Immunohistochemistry
Predicted cell location: Cytoplasm
Positive control: Human esophagus cancer
Recommended dilution: 25-100    Predicted cell location: Cytoplasm
Positive control: Human cervical cancer
Recommended dilution: 25-100