Product overview Description Anti-VPS35 rabbit polyclonal antibody Applications ELISA, IHC Immunogen Fusion protein of human VPS35 Reactivity Human, Mouse Content 1.2 mg/ml Host species Rabbit Ig class Immunogen-specific rabbit IgG Purification Antigen affinity purification
Target information Symbol VPS35 Full name vacuolar protein sorting 35 homolog (S. cerevisiae) Synonyms MEM3; PARK17 Swissprot Q96QK1
Target Background This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex.