Anti-MASP1 antibody

Anti-MASP1 antibody

Cat. No.     JC220954
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-MASP1 rabbit polyclonal antibody
Applications        ELISA, WB 
Immunogen               Fusion protein of human MASP1
Reactivity                 Human, Mouse, Rat
Content                     0.5 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification

Target information
Symbol                 MASP1
Full name                 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
Synonyms    3MC1; MAP1; MASP; RaRF; CRARF; MASP3; MAp44; PRSS5; CRARF1
Swissprot    P48740

Target Background
This gene encodes a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. The encoded protein is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. The encoded protein is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation. A splice variant of this gene which lacks the serine protease domain functions as an inhibitor of the complement pathway. Alternate splicing results in multiple transcript variants.

Applications
Western blotting
Predicted band size:79 kDa
Positive control:Mouse brain tissue,Human heart tissue,Rat liver tissue,Mouse heart tissue,Mouse liver tissue,Hela cell lysates 
Recommended dilution: 200-1000