Product overview
Description Anti-PTPRC rabbit polyclonal antibody
Applications ELISA, IHC
Immunogen Synthetic peptide of human PTPRC
Reactivity Human, Mouse, Rat
Content 0.3 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Anti-PTPRC antibody Target information
Symbol PTPRC
Full name protein tyrosine phosphatase, receptor type, C
Synonyms LCA; LY5; B220; CD45; L-CA; T200; CD45R; GP180
Swissprot P08575
Target Background
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling.
Anti-PTPRC antibody Applications
Immunohistochemistry
Predicted cell location: Cytoplasm
Positive control: Human Lymphoma
Recommended dilution: 50-200 Predicted cell location: Cytoplasm
Positive control: Human gastric cancer
Recommended dilution: 50-200