Anti-LMNA antibody

Anti-LMNA antibody

Cat. No.     JC220927
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-LMNA rabbit polyclonal antibody
Applications        ELISA, WB, IHC 
Immunogen               Fusion protein of human LMNA
Reactivity                 Human, Mouse, Rat
Content                     0.7 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification

Target information
Symbol                 LMNA
Full name                 lamin A/C
Synonyms    FPL; IDC; LFP; CDDC; EMD2; FPLD; HGPS; LDP1; LMN1; LMNC; PRO1; CDCD1; CMD1A; FPLD2; LMNL1; CMT2B1; LGMD1B
Swissprot    P02545

Target Background
The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants.

Applications
Immunohistochemistry
Predicted cell location: Nucleus
Positive control: Human liver cancer
Recommended dilution: 100-300    Predicted cell location: Nucleus
Positive control: Human colon cancer
Recommended dilution: 100-300